I have to modify lines 17046 and 17458 of configure to get MacOS to find my libboost_python, since homebrew's current version calls the library libboost_pythonXX.dylib where XX is 27 or 38 etc, depending on the version of Python used. configure is just hunting for libboost_python.so which is symlinked on Linux but not on MacOS homebrew. Making such a symlink is dangerous if you have multiple python versions. Suggest modifying configure to use python version to go looking for libboost_python in the right place on Darwin.